Monday, January 18, 2016

Early Antibiotic Use Increases Celiac Risk

From the archive files: Research from American Journal of Epidemiology. Jul2014, Vol. 180 Issue 1, p76-85.
Document Type:

July 2014

Association of Maternal Education, Early Infections, and Antibiotic Use With Celiac Disease: A Population-Based Birth Cohort Study in Northeastern Italy.

suggests that having repeated infectious episodes treated with antibiotics under twelve months old provide increased risk for celiac disease.
Having three or more parental-reported infectious episodes, regardless of type of infection, during the first six months of life was associated with a significantly increased risk for later celiac disease, and this remained after adjusting for infant feeding and socioeconomic status (odds ratio [OR] 1.5; 95% confidence interval [CI], 1.1-2.0; P=0.014). The celiac disease risk increased synergistically if, in addition to having several infectious episodes, infants were introduced to dietary gluten in large amounts, compared to small or medium amounts, after breastfeeding was discontinued (OR 5.6; 95% CI, 3.1-10; P<0.001).

Take Home Message:

Prevent infections in newborns
Hesitate to use antibiotics
Introduce gluten in small amounts, preferably while breastfeeding.

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